In order to study the multi-phase wellbore flow law of the two-layer continuous tube lift hydrate, a multi-phase wellbore flow model using the two-layer continuous tube solid fluidization was established in this paper, and the model was solved by the finite difference method. Based on the above model, the multi-phase wellbore flow behavior of gas hydrate production in a case well in the South China Sea using solid fluidization of two-layer continuous pipe was simulated. The results show that the solid phase content and liquid phase content are relatively stable and the gas content is 0 when the fluid rises to a height of more than 700 meters. When the fluid rises to a height more than 700 meters, the solid phase hydrate begins to decompose gradually. When the density and displacement of drilling fluid are too high or too low, the bottomhole pressure will escape from the safety window and threaten the safety of well control. Therefore, the reasonable selection of drilling parameters is particularly important for ensuring well control safety.