Both fear factors and prey refuge have important effects in predation on the ecos-ystems. A class of reaction diffusion predator-prey models with fear effect and prey refuge is studied. We first provide the local asymptotic stability of the equilibrium point by using the linearization method and local bifurcation theory. Next, the existence of Hopf bifurcation and limit cycle is examined by choosing the ratio of un-protected prey as the bifurcation parameter. The results show that the existence of the refuge leads to Hopf bifurcation and spatially homogeneous periodic solution, and the addition of diffusion leads to new Hopf bifurcation points and inhomogeneous periodic solutions. This shows that the biological population can coexist by setting up an appropriate prey refuge or reducing the diffusion of predators. Finally, the conclusions are verified through numerical simulation.